KL

Across TCGA cell cohorts, KL mutation is significantly associated with the RNA expression of many other genes, with 186 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KL-associated genes across cancer lineages are TAS2R7, PF4V1, and CHIA. Each is linked with KL in more than 2 cancer types. Because this analysis shows association rather than direction, both KL-to-partner and partner-to-KL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R7 grouped by KL-low versus KL-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KL→partner) and Y-score (partner→KL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TAS2R7 →	+0.017	+4.058	<.001	.009	3	3
LUNG_NSCLC_LUAD	PF4V1 →	+0.955	+3.536	<.001	.001	3	1
LUNG_NSCLC_LUAD	CHIA →	+0.803	+2.980	.001	.007	3	1
LUNG_NSCLC_LUAD	OR3A3 →	+0.055	+2.980	<.001	.007	3	1
LUNG_NSCLC_LUAD	USP50 →	+0.106	+3.528	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR52W1 →	+0.049	+3.906	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 186 associations by consensus.

TAS2R7 by KL expression — BLOOD_Lymphoma

Explore this box plot interactively →