KIZ

Across TCGA pan-cancer cohorts, KIZ mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KIZ data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KIZ mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KIZ expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where KIZ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.128	1.000	.016	14	view →
UCEC	DFS	Tertile	All	1.000	0.788	.006	10	view →
LSCC	DFS	Tertile	All	1.000	0.874	.003	9	view →
GBM	DFS	Quartile	All	0.977	0.670	.027	2	view →
CCRCC	OS	Median	III,IV	0.360	0.891	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KIZ–LUAD (OS)

Open the LUAD breakdown →