KIZ

Across TCGA patient cohorts, KIZ mutation is significantly associated with the RNA expression of many other genes, with 3,979 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIZ-associated genes across cancer lineages are RN7SL828P, RNA5SP511, and FABP5P13. Each is linked with KIZ in more than 2 cancer types. Because this analysis shows association rather than direction, both KIZ-to-partner and partner-to-KIZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL828P grouped by KIZ-low versus KIZ-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIZ→partner) and Y-score (partner→KIZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL828P →	+0.079	+4.328	<.001	.007	3	3
LUSC	RNA5SP511 →	+0.199	+3.474	<.001	.004	3	2
GBM	FABP5P13 →	+0.123	+5.614	<.001	.001	3	2
HNSC	RNU1-57P →	+0.169	+4.608	<.001	.005	3	2
UCEC	NUTF2 →	+0.443	+2.354	<.001	<.001	3	2
UCEC	ERI1 →	+0.508	+2.064	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,979 associations by consensus.

RN7SL828P by KIZ expression — SKCM

Explore this box plot interactively →