KIZ

Across TCGA patient cohorts, KIZ mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIZ-associated genes across cancer lineages are MEK1, ATM, and 14-3-3_beta. Each is linked with KIZ in more than 1 cancer types. Because this analysis shows association rather than direction, both KIZ-to-partner and partner-to-KIZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by KIZ-low versus KIZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIZ→partner) and Y-score (partner→KIZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.471	+2.392	<.001	<.001	3	2
UCEC	ATM →	-0.368	-1.986	.021	.029	3	2
UCEC	14-3-3_beta →	-0.088	-1.673	.013	.040	3	1
UCEC	eIF4E →	+0.205	+2.000	.005	.003	3	1
UCEC	A-Raf_pS299 →	-0.084	-2.115	.046	.017	3	1
UCEC	ACC1 →	+0.271	+2.183	.034	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MEK1 by KIZ expression — UCEC

Explore this box plot interactively →