KITLG

Across TCGA pan-cancer cohorts, KITLG mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KITLG data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KITLG mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KITLG expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where KITLG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.363	0.818	.006	21	view →
LSCC	DFS	Median	All	0.616	0.835	.014	4	view →
LUAD	OS	Median	II,III,IV	1.000	0.899	.040	3	view →
GBM	OS	Quartile	All	0.388	0.816	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KITLG–HNSC (DFS)

Open the HNSC breakdown →