KITLG

Across TCGA cell cohorts, KITLG RNA expression is significantly associated with the go_rna of many other GO terms, with 3,407 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KITLG-associated GO terms across cancer lineages are Positive regulation of hematopoietic progenitor cell differentiation, L-tryptophan metabolic process, and Post-Golgi vesicle-mediated transport. Each is linked with KITLG in more than 7 cancer types. Because this analysis shows association rather than direction, both KITLG-to-partner and partner-to-KITLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of hematopoietic progenitor cell differentiation grouped by KITLG-low versus KITLG-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KITLG→partner) and Y-score (partner→KITLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of hematopoietic progenitor cell differentiation →	+0.129	+2.097	.001	.001	3	8
LUNG_NSCLC_LUAD	L-tryptophan metabolic process →	-0.128	-0.995	.009	.008	3	7
BONE	Post-Golgi vesicle-mediated transport →	+0.051	+1.669	.008	.003	3	7
BONE	Cellular response to hepatocyte growth factor stimulus →	+0.206	+2.102	<.001	.001	3	7
BONE	Positive regulation of neuron apoptotic process →	+0.110	+1.878	.003	.008	3	7
LUNG_NSCLC_LUAD	Response to forskolin →	+0.124	+1.193	.004	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,407 associations by consensus.

Positive regulation of hematopoietic progenitor cell differentiation by KITLG expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →