KIT

Across TCGA patient cohorts, KIT protein abundance is significantly associated with the RNA expression of many other genes, with 8,974 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible KIT-associated genes across cancer lineages are CXCL8, AQP9, and FFAR2. Each is linked with KIT in more than 4 cancer types. Because this analysis shows association rather than direction, both KIT-to-partner and partner-to-KIT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KIT versus CXCL8 in COAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIT→partner) and Y-score (partner→KIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CXCL8 →	+1.834	+1.689	<.001	<.001	3	5
PDAC	AQP9 →	+1.279	+1.320	<.001	<.001	3	4
HNSC	FFAR2 →	+1.121	+1.124	.005	<.001	3	4
PDAC	FCGR3B →	+1.618	+1.205	<.001	<.001	3	4
HNSC	CXCR1 →	+1.138	+0.996	<.001	<.001	3	4
HNSC	CXCL3 →	+1.250	+1.167	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,974 associations by consensus.

KIT vs CXCL8 — COAD

Explore this scatter interactively →