KIT

Across TCGA patient cohorts, KIT mutation is significantly associated with the RNA expression of many other genes, with 8,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIT-associated genes across cancer lineages are FANCE, CLN6, and PYY2. Each is linked with KIT in more than 3 cancer types. Because this analysis shows association rather than direction, both KIT-to-partner and partner-to-KIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCE grouped by KIT-low versus KIT-high in TGCT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIT→partner) and Y-score (partner→KIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	FANCE →	+1.013	+3.743	<.001	<.001	3	4
SKCM	CLN6 →	+0.566	+2.279	<.001	.005	3	4
LUSC	PYY2 →	+1.141	+2.593	.002	.006	3	4
BLCA	SP8 →	+0.545	+2.785	<.001	.008	3	4
SKCM	CMTM8 →	-0.871	-2.312	.003	.005	3	4
TGCT	RAC3 →	+0.726	+2.584	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,777 associations by consensus.

FANCE by KIT expression — TGCT

Explore this box plot interactively →