KIT

Across TCGA patient cohorts, KIT mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIT-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with KIT in more than 2 cancer types. Because this analysis shows association rather than direction, both KIT-to-partner and partner-to-KIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KIT-low versus KIT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIT→partner) and Y-score (partner→KIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.120	+1.524	.002	.008	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.329	-1.459	.008	.011	3	3
COAD	PDCD4 →	-0.577	-3.321	<.001	.009	3	3
UCEC	ATM →	-0.505	-2.137	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+0.882	+2.186	.003	.032	3	3
COAD	MIG-6 →	+0.098	+2.281	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Notch1 by KIT expression — UCEC

Explore this box plot interactively →