KIT

Across TCGA cell cohorts, KIT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,482 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KIT-associated GO terms across cancer lineages are Regulation of small intestine smooth muscle contraction, Positive regulation of small intestine smooth muscle contraction, and Negative regulation of myoblast fusion. Each is linked with KIT in more than 17 cancer types. Because this analysis shows association rather than direction, both KIT-to-partner and partner-to-KIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of small intestine smooth muscle contraction grouped by KIT-low versus KIT-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIT→partner) and Y-score (partner→KIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of small intestine smooth muscle contraction →	+1.896	+3.830	<.001	<.001	3	18
BONE	Positive regulation of small intestine smooth muscle contraction →	+1.896	+3.830	<.001	<.001	3	18
STOMACH	Negative regulation of myoblast fusion →	+0.123	+1.045	.003	.002	3	6
STOMACH	Regulation of intracellular estrogen receptor signaling pathway →	+0.067	+0.750	.002	.003	3	6
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.122	+0.759	.003	.001	3	6
STOMACH	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.087	+0.781	<.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,482 associations by consensus.

Regulation of small intestine smooth muscle contraction by KIT expression — BONE

Explore this box plot interactively →