KIRREL3-AS2

Across TCGA pan-cancer cohorts, KIRREL3-AS2 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated KIRREL3-AS2 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KIRREL3-AS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KIRREL3-AS2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and OV show a favorable association.

ACC, HNSC, and THYM are the cancer types where KIRREL3-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.168	0.821	<.001	66	view →
HNSC	OS	Tertile	All	0.242	0.627	<.001	54	view →
THYM	DFS	Tertile	II,III,IV	0.145	0.873	<.001	36	view →
SKCM	OS	Tertile	IV	0.179	0.755	<.001	36	view →
MESO	OS	Tertile	II,III,IV	0.321	0.596	.006	36	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	28	view →
BLCA	DFS	Tertile	III,IV	0.307	0.582	.005	27	view →
CHOL	DFS	Tertile	III,IV	0.133	0.779	.038	15	view →
KIRC	DFS	Tertile	III,IV	0.206	0.489	.047	12	view →
PAAD	OS	Tertile	II,III,IV	1.000	0.365	.041	9	view →
OV	DFS	Quartile	III,IV	0.197	0.138	.033	8	view →
ESCA	OS	Quartile	III,IV	0.606	0.360	.032	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

KIRREL3-AS2–ACC (OS)

Open the ACC breakdown →