KIRREL3-AS1

Across TCGA pan-cancer cohorts, KIRREL3-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated KIRREL3-AS1 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher KIRREL3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KIRREL3-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

THCA, THYM, and ACC are the cancer types where KIRREL3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	0.786	0.950	<.001	99	view →
THYM	OS	Tertile	II,III,IV	0.881	0.974	.003	75	view →
ACC	DFS	Median	All	0.219	0.607	<.001	55	view →
ESCA	OS	Quartile	III,IV	0.815	0.435	.002	43	view →
LIHC	OS	Tertile	III,IV	0.123	0.560	<.001	39	view →
COAD	OS	Tertile	IV	0.140	0.691	<.001	36	view →
CESC	DFS	Tertile	All	0.342	0.604	.004	30	view →
BLCA	OS	Tertile	IV	0.269	0.483	.007	27	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
UVM	OS	Tertile	III,IV	0.271	0.870	.009	17	view →
HNSC	OS	Tertile	IV	0.732	0.590	.025	16	view →
BRCA	DFS	Median	IV	0.335	0.671	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

KIRREL3-AS1–THCA (OS)

Open the THCA breakdown →