KIRREL2

Across TCGA pan-cancer cohorts, KIRREL2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KIRREL2 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher KIRREL2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KIRREL2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

CHOL, READ, and BLCA are the cancer types where KIRREL2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Median	All	0.019	0.800	<.001	24	view →
READ	OS	Median	II,III,IV	0.173	0.818	<.001	21	view →
BLCA	OS	Median	IV	0.132	0.599	.004	21	view →
CESC	OS	Median	All	0.094	0.587	.018	6	view →
PRAD	DFS	Median	All	0.085	0.774	.001	6	view →
UCEC	DFS	Median	All	0.962	0.624	.014	6	view →
LUSC	DFS	Median	All	0.672	0.380	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KIRREL2–CHOL (OS)

Open the CHOL breakdown →