Across TCGA pan-cancer cohorts, KIRREL1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KIRREL1 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KIRREL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KIRREL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where KIRREL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.205	0.748	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.943	0.426	.005	34	view →
LUAD	OS	Median	All	1.000	0.806	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: KIRREL1 tumor-vs-normal RNA expression · all KIRREL1 data types