Across TCGA patient cohorts, KIRREL1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIRREL1-associated genes across cancer lineages are Rab11, PRAS40_pT246, and TFRC. Each is linked with KIRREL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIRREL1-to-partner and partner-to-KIRREL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIRREL1→partner) and Y-score (partner→KIRREL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rab11 →	-0.274	-3.169	.009	.018	3	3
UCEC	PRAS40_pT246 →	+0.121	+1.362	.016	.034	3	3
UCEC	TFRC →	+0.483	+3.584	.002	.002	3	3
UCEC	eIF4E →	+0.195	+1.857	.001	<.001	3	2
UCEC	eIF4G →	+0.222	+1.584	.015	.017	3	2
UCEC	ERK2 →	+0.199	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Exploration

KIRREL1 survival (RNA) · tumor vs normal (RNA) · all KIRREL1 data types