Across TCGA pan-cancer cohorts, KIRREL1-IT1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of KIRREL1-IT1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KIRREL1-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIRREL1-IT1 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.
HNSC, KIRC, and KIRP are the cancer types where KIRREL1-IT1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIRREL1-IT1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.