KIR3DX1

Across TCGA patient cohorts, KIR3DX1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIR3DX1-associated genes across cancer lineages are Rictor_pT1135, HER2, and MEK1. Each is linked with KIR3DX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIR3DX1-to-partner and partner-to-KIR3DX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by KIR3DX1-low versus KIR3DX1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DX1→partner) and Y-score (partner→KIR3DX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rictor_pT1135 →	-0.131	-2.296	.017	.005	3	3
UCEC	HER2 →	+0.401	+2.999	.021	.035	3	2
UCEC	MEK1 →	+0.449	+3.584	.001	.002	3	2
UCEC	STAT3_pY705 →	-0.379	-1.896	<.001	.015	3	2
UCEC	Bak →	+0.224	+2.459	.019	.019	3	2
UCEC	4E-BP1 →	+0.253	+2.999	.015	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Rictor_pT1135 by KIR3DX1 expression — SKCM

Explore this box plot interactively →