KIR3DX1

Across TCGA cell cohorts, KIR3DX1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KIR3DX1-associated genes across cancer lineages are MAGEB4, OLIG3, and MINAR2. Each is linked with KIR3DX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIR3DX1-to-partner and partner-to-KIR3DX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by KIR3DX1-low versus KIR3DX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DX1→partner) and Y-score (partner→KIR3DX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	OLIG3 →	+0.018	+3.247	.008	.001	3	1
LARGE_INTESTINE	MINAR2 →	+0.030	+2.882	.001	.005	3	1
LARGE_INTESTINE	GPX5 →	+0.152	+2.688	.003	.008	3	1
SKIN	PAK5 →	+0.048	+3.658	.008	.005	3	1
SKIN	CLEC4E →	+0.093	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MAGEB4 by KIR3DX1 expression — LARGE_INTESTINE

Explore this box plot interactively →