KIR3DL2

Across TCGA patient cohorts, KIR3DL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,018 significant associations in total. THYM shows the largest number of these associations.

The most reproducible KIR3DL2-associated GO terms across cancer lineages are Regulation of leukocyte proliferation, T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, and Regulation of B cell activation. Each is linked with KIR3DL2 in more than 30 cancer types. Because this analysis shows association rather than direction, both KIR3DL2-to-partner and partner-to-KIR3DL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of leukocyte proliferation grouped by KIR3DL2-low versus KIR3DL2-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DL2→partner) and Y-score (partner→KIR3DL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Regulation of leukocyte proliferation →	+0.096	+0.370	.001	.001	3	31
SCLC	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell →	+0.324	+0.441	<.001	<.001	3	31
SCLC	Regulation of B cell activation →	+0.110	+0.292	<.001	.001	3	30
SCLC	Regulation of leukocyte apoptotic process →	+0.102	+0.346	.001	.001	3	29
SCLC	Alpha-beta T cell activation →	+0.089	+0.336	<.001	<.001	3	29
SCLC	Positive regulation of B cell proliferation →	+0.094	+0.404	<.001	<.001	2	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,018 associations by consensus.

Regulation of leukocyte proliferation by KIR3DL2 expression — SCLC

Explore this box plot interactively →