KIR3DL2

Across TCGA patient cohorts, KIR3DL2 protein abundance is significantly associated with the RNA expression of many other genes, with 337 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible KIR3DL2-associated genes across cancer lineages are CRISPLD2, CLEC11A, and MPP6. Each is linked with KIR3DL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIR3DL2-to-partner and partner-to-KIR3DL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KIR3DL2 versus CRISPLD2 in CCRCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DL2→partner) and Y-score (partner→KIR3DL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CRISPLD2 →	+1.038	+0.679	.003	<.001	3	1
CCRCC	CLEC11A →	+1.266	+0.774	.001	.006	3	1
CCRCC	MPP6 →	-0.865	-0.625	.002	.004	3	1
CCRCC	LHX6 →	+0.605	+0.604	.003	.008	3	1
CCRCC	EHHADH →	-1.378	-0.722	<.001	<.001	3	1
CCRCC	CRYZ →	-0.861	-0.805	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 337 associations by consensus.

KIR3DL2 vs CRISPLD2 — CCRCC

Explore this scatter interactively →