KIR3DL2

Across TCGA patient cohorts, KIR3DL2 mutation is significantly associated with the RNA expression of many other genes, with 4,834 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIR3DL2-associated genes across cancer lineages are DCTPP1, DIABLO, and JPT2. Each is linked with KIR3DL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIR3DL2-to-partner and partner-to-KIR3DL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCTPP1 grouped by KIR3DL2-low versus KIR3DL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DL2→partner) and Y-score (partner→KIR3DL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCTPP1 →	+0.564	+2.321	<.001	.006	3	4
LUAD	DIABLO →	+0.397	+3.251	<.001	.008	3	4
UCEC	JPT2 →	+0.465	+2.354	<.001	<.001	3	4
LUAD	CKS1B →	+0.760	+3.193	.001	.009	3	4
UCEC	MYBL2 →	+0.724	+1.752	.001	.004	3	4
UCEC	NABP2 →	+0.314	+1.864	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,834 associations by consensus.

DCTPP1 by KIR3DL2 expression — UCEC

Explore this box plot interactively →