KIR3DL2

Across TCGA patient cohorts, KIR3DL2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIR3DL2-associated genes across cancer lineages are 4E-BP1_pS65, eEF2, and ERK2. Each is linked with KIR3DL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIR3DL2-to-partner and partner-to-KIR3DL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pS65 grouped by KIR3DL2-low versus KIR3DL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DL2→partner) and Y-score (partner→KIR3DL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1_pS65 →	+0.197	+3.000	.001	<.001	3	3
UCEC	eEF2 →	+0.325	+1.662	.010	.011	3	3
UCEC	ERK2 →	+0.187	+1.662	.005	.011	3	3
LUAD	mTOR_pS2448 →	-0.304	-3.000	.003	.036	3	2
LUSC	FASN →	+0.550	+2.816	.023	.036	3	2
UCEC	14-3-3_beta →	-0.085	-3.295	.016	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

4E-BP1_pS65 by KIR3DL2 expression — SKCM

Explore this box plot interactively →