KIR3DL1

Across TCGA patient cohorts, KIR3DL1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIR3DL1-associated genes across cancer lineages are eEF2, p38-MAPK_pT180_Y182, and Caspase-7-cleavedD198. Each is linked with KIR3DL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIR3DL1-to-partner and partner-to-KIR3DL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KIR3DL1-low versus KIR3DL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DL1→partner) and Y-score (partner→KIR3DL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.319	+2.459	.023	.019	3	4
SKCM	p38-MAPK_pT180_Y182 →	-0.313	-1.925	.012	.004	3	3
UCEC	Caspase-7-cleavedD198 →	+0.818	+3.700	<.001	.001	3	3
LUAD	p38-MAPK →	-0.225	-2.890	<.001	.001	3	2
LUAD	4E-BP1 →	+0.363	+3.012	.002	.018	2	3
UCEC	MEK1 →	+0.412	+2.807	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eEF2 by KIR3DL1 expression — UCEC

Explore this box plot interactively →