KIR3DL1

Across TCGA cell cohorts, KIR3DL1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIR3DL1-associated genes across cancer lineages are FAM240A, DAZ2, and CT47A6. Each is linked with KIR3DL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIR3DL1-to-partner and partner-to-KIR3DL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM240A grouped by KIR3DL1-low versus KIR3DL1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DL1→partner) and Y-score (partner→KIR3DL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAM240A →	+0.052	+4.285	<.001	.007	3	2
OVARY	DAZ2 →	+0.106	+5.807	<.001	.001	3	1
OVARY	CT47A6 →	+0.030	+5.807	<.001	.001	3	1
CNS	RGS21 →	+0.012	+4.981	<.001	.008	3	1
STOMACH	SPHKAP →	+0.011	+4.432	<.001	.003	3	1
STOMACH	VN1R3 →	+0.020	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FAM240A by KIR3DL1 expression — STOMACH

Explore this box plot interactively →