Across TCGA pan-cancer cohorts, KIR2DS4 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KIR2DS4 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KIR2DS4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KIR2DS4 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

UCEC and SKCM are the cancer types where KIR2DS4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	II,III,IV	0.624	0.217	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: KIR2DS4 tumor-vs-normal RNA expression · all KIR2DS4 data types