Across TCGA patient cohorts, KIR2DS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,317 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KIR2DS4-associated GO terms across cancer lineages are Response to interleukin-15, Alpha-beta T cell activation, and Cell-cell adhesion mediated by integrin. Each is linked with KIR2DS4 in more than 26 cancer types. Because this analysis shows association rather than direction, both KIR2DS4-to-partner and partner-to-KIR2DS4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR2DS4→partner) and Y-score (partner→KIR2DS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Response to interleukin-15 →	+0.226	+0.699	<.001	<.001	3	27
SCLC	Alpha-beta T cell activation →	+0.114	+0.650	<.001	<.001	3	27
SCLC	Cell-cell adhesion mediated by integrin →	+0.270	+0.660	<.001	<.001	2	27
SCLC	Negative regulation of cell activation →	+0.121	+0.667	<.001	<.001	3	26
SCLC	Positive regulation of interleukin-12 production →	+0.130	+0.503	<.001	<.001	3	25
SCLC	Positive regulation of leukocyte proliferation →	+0.124	+0.547	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,317 associations by consensus.

Exploration

KIR2DS4 survival (RNA) · tumor vs normal (RNA) · all KIR2DS4 data types