Across TCGA patient cohorts, KIR2DS4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIR2DS4-associated genes across cancer lineages are TIGAR, ATM, and BRD4. Each is linked with KIR2DS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIR2DS4-to-partner and partner-to-KIR2DS4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR2DS4→partner) and Y-score (partner→KIR2DS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.193	+3.026	.028	.019	3	1
UCEC	ATM →	-0.668	-3.000	.010	.037	3	1
UCEC	BRD4 →	+0.332	+3.007	.032	.019	3	1
UCEC	4E-BP1 →	+0.566	+3.000	<.001	.037	3	1
SKCM	A-Raf_pS299 →	+0.204	+2.820	.013	.035	3	1
UCEC	PCNA →	+0.301	+3.000	.016	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

KIR2DS4 survival (RNA) · tumor vs normal (RNA) · all KIR2DS4 data types