KIR2DL4

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, KIR2DL4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIR2DL4-associated genes across cancer lineages are Caspase-7-cleavedD198, p21, and 14-3-3_beta. Each is linked with KIR2DL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIR2DL4-to-partner and partner-to-KIR2DL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR2DL4→partner) and Y-score (partner→KIR2DL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADCaspase-7-cleavedD198 →+1.409+2.815.001.03633
LUSCp21 →-0.340-2.450.030.01932
UCEC14-3-3_beta →-0.099-2.558.008.01032
UCECeIF4G →+0.267+3.169.021.01832
UCECKu80 →+0.229+2.183.009.00132
UCECp38-MAPK_pT180_Y182 →-0.362-1.700.032.04232
Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

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