KIR2DL3

Across TCGA patient cohorts, KIR2DL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,742 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KIR2DL3-associated GO terms across cancer lineages are Response to interleukin-15, Natural killer cell degranulation, and Regulation of leukocyte proliferation. Each is linked with KIR2DL3 in more than 26 cancer types. Because this analysis shows association rather than direction, both KIR2DL3-to-partner and partner-to-KIR2DL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to interleukin-15 grouped by KIR2DL3-low versus KIR2DL3-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR2DL3→partner) and Y-score (partner→KIR2DL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Response to interleukin-15 →	+0.227	+0.370	<.001	<.001	3	27
SCLC	Natural killer cell degranulation →	+0.190	+0.351	<.001	<.001	3	26
SCLC	Regulation of leukocyte proliferation →	+0.140	+0.373	<.001	<.001	3	26
SCLC	Alpha-beta T cell activation →	+0.126	+0.402	<.001	<.001	3	26
SCLC	Antigen processing and presentation of exogenous peptide antigen via MHC class II →	+0.400	+0.353	<.001	<.001	3	25
SCLC	Myeloid leukocyte activation →	+0.127	+0.427	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,742 associations by consensus.

Response to interleukin-15 by KIR2DL3 expression — SCLC

Explore this box plot interactively →