KIR2DL3

Across TCGA cell cohorts, KIR2DL3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIR2DL3-associated genes across cancer lineages are PRSS38 and OR13C7. Each is linked with KIR2DL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIR2DL3-to-partner and partner-to-KIR2DL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS38 grouped by KIR2DL3-low versus KIR2DL3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR2DL3→partner) and Y-score (partner→KIR2DL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRSS38 →	+0.061	+4.392	<.001	.003	3	1
LARGE_INTESTINE	OR13C7 →	+0.026	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PRSS38 by KIR2DL3 expression — OESOPHAGUS

Explore this box plot interactively →