KIR2DL1

Across TCGA patient cohorts, KIR2DL1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIR2DL1-associated genes across cancer lineages are c-Met_pY1235, NDRG1_pT346, and PCNA. Each is linked with KIR2DL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIR2DL1-to-partner and partner-to-KIR2DL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by KIR2DL1-low versus KIR2DL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR2DL1→partner) and Y-score (partner→KIR2DL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.077	+1.807	.012	.027	3	3
LUSC	NDRG1_pT346 →	+1.068	+3.000	.015	.035	3	2
UCEC	PCNA →	+0.251	+1.807	.004	.027	3	2
UCEC	ATM →	-0.458	-3.156	.014	.018	3	2
UCEC	Bcl-2 →	-0.384	-3.150	.007	.019	3	2
UCEC	4E-BP1 →	+0.352	+3.489	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

c-Met_pY1235 by KIR2DL1 expression — UCEC

Explore this box plot interactively →