KIN

Across TCGA pan-cancer cohorts, KIN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KIN data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KIN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KIN expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where KIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.891	0.602	.009	11	view →
HNSC	DFS	Median	All	0.900	0.982	.005	10	view →
PDAC	OS	Median	IV	0.491	0.836	.024	10	view →
GBM	DFS	Quartile	All	0.489	0.297	.022	5	view →
CCRCC	DFS	Tertile	III,IV	0.750	0.948	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KIN–LSCC (OS)

Open the LSCC breakdown →