KIFC3

Across TCGA pan-cancer cohorts, KIFC3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KIFC3 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KIFC3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KIFC3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where KIFC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.620	.014	40	view →
HNSC	OS	Median	II,III,IV	1.000	0.925	.002	29	view →
CCRCC	OS	Quartile	All	1.000	0.881	.027	9	view →
PDAC	DFS	Median	III,IV	0.501	0.800	.013	9	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	8	view →
LSCC	OS	Median	All	0.922	1.000	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KIFC3–UCEC (OS)

Open the UCEC breakdown →