KIFC2

Across TCGA patient cohorts, KIFC2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIFC2-associated genes across cancer lineages are Ku80, p70-S6K, and p90 RSK. Each is linked with KIFC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIFC2-to-partner and partner-to-KIFC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by KIFC2-low versus KIFC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIFC2→partner) and Y-score (partner→KIFC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.314	+2.183	.011	.035	3	1
UCEC	p70-S6K →	+0.202	+2.196	.045	.034	3	1
UCEC	p90 RSK →	+0.228	+3.009	.023	.019	3	1
UCEC	p62 Lck ligand →	+0.419	+3.321	.014	.010	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Ku80 by KIFC2 expression — UCEC

Explore this box plot interactively →