KIFC2

Across TCGA cell cohorts, KIFC2 mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIFC2-associated genes across cancer lineages are KLHL40, TAS1R2, and TRIM49B. Each is linked with KIFC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIFC2-to-partner and partner-to-KIFC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by KIFC2-low versus KIFC2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIFC2→partner) and Y-score (partner→KIFC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KLHL40 →	+0.019	+3.906	<.001	.009	3	2
BLOOD_Leukemia	TAS1R2 →	+0.008	+3.440	<.001	.001	3	2
BLOOD_Myeloma	TRIM49B →	+0.368	+4.285	.003	.003	3	1
BLOOD_Myeloma	GSTA2 →	+0.016	+3.906	<.001	.009	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1
SKIN	TPH2 →	+0.055	+3.145	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

KLHL40 by KIFC2 expression — BLOOD_Myeloma

Explore this box plot interactively →