KIFC1

Across TCGA patient cohorts, KIFC1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIFC1-associated genes across cancer lineages are ACC1, PKC-delta_pS664, and STAT3_pY705. Each is linked with KIFC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIFC1-to-partner and partner-to-KIFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by KIFC1-low versus KIFC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIFC1→partner) and Y-score (partner→KIFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.305	+1.502	.022	.030	3	2
UCEC	PKC-delta_pS664 →	-0.129	-1.502	.003	.030	3	2
UCEC	STAT3_pY705 →	-0.295	-2.000	.002	.029	3	2
UCEC	TFRC →	+0.410	+1.502	.035	.030	3	2
UCEC	Cyclin-B1 →	+0.525	+3.321	.010	.009	3	2
COAD	ASNS →	+0.431	+2.815	.047	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ACC1 by KIFC1 expression — UCEC

Explore this box plot interactively →