KIFC1

Across TCGA cell cohorts, KIFC1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIFC1-associated genes across cancer lineages are SIGLEC8, OR10G3, and CYP39A1. Each is linked with KIFC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIFC1-to-partner and partner-to-KIFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by KIFC1-low versus KIFC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIFC1→partner) and Y-score (partner→KIFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SIGLEC8 →	+0.025	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10G3 →	+0.006	+6.266	<.001	<.001	3	1
BLOOD_Leukemia	CYP39A1 →	+0.151	+3.091	<.001	.006	3	1
BLOOD_Leukemia	GUCY1A2 →	+0.265	+3.540	.001	.005	3	1
BLOOD_Leukemia	PCDH19 →	+0.194	+4.415	.001	.001	3	1
BLOOD_Leukemia	INSM2 →	+0.259	+3.091	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SIGLEC8 by KIFC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →