KIFAP3

Across TCGA patient cohorts, KIFAP3 mutation is significantly associated with the RNA expression of many other genes, with 5,437 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIFAP3-associated genes across cancer lineages are MIR5089, CEP250, and MDC1. Each is linked with KIFAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIFAP3-to-partner and partner-to-KIFAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5089 grouped by KIFAP3-low versus KIFAP3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIFAP3→partner) and Y-score (partner→KIFAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR5089 →	+0.543	+2.252	<.001	.005	3	3
UCEC	CEP250 →	+0.369	+2.169	<.001	<.001	3	3
UCEC	MDC1 →	+0.764	+2.485	<.001	<.001	3	3
UCEC	LEMD2 →	+0.240	+2.479	.009	.001	3	3
UCEC	TEDC2 →	+0.739	+1.914	<.001	<.001	3	3
UCEC	FBXO45 →	+0.454	+2.169	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,437 associations by consensus.

MIR5089 by KIFAP3 expression — LUSC

Explore this box plot interactively →