KIFAP3

Across TCGA patient cohorts, KIFAP3 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIFAP3-associated genes across cancer lineages are PCNA, MEK1, and S6_pS240_S244. Each is linked with KIFAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIFAP3-to-partner and partner-to-KIFAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KIFAP3-low versus KIFAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIFAP3→partner) and Y-score (partner→KIFAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.248	+2.502	<.001	.001	3	3
UCEC	MEK1 →	+0.474	+3.807	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.361	+1.514	.009	.015	3	2
UCEC	c-Kit →	-0.177	-1.247	.025	.045	3	2
UCEC	14-3-3_beta →	-0.113	-3.880	<.001	<.001	3	1
UCEC	eEF2 →	+0.368	+3.807	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

PCNA by KIFAP3 expression — UCEC

Explore this box plot interactively →