KIF9

Across TCGA pan-cancer cohorts, KIF9 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KIF9 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KIF9 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KIF9 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

HNSC, UCEC, and DLBC are the cancer types where KIF9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.169	0.710	.008	30	view →
UCEC	DFS	Median	All	0.971	0.607	.003	22	view →
DLBC	OS	Median	II,III,IV	0.118	0.802	.025	12	view →
BLCA	OS	Median	All	0.188	0.687	.020	9	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	6	view →
STAD	OS	Median	IV	1.000	0.299	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KIF9–HNSC (OS)

Open the HNSC breakdown →