KIF7

Across TCGA pan-cancer cohorts, KIF7 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of KIF7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KIF7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KIF7 is over-expressed in tumor.

HNSC, LSCC, and LUAD are the cancer types where KIF7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.605	<.001	8	view →
LSCC	Female	II,III,IV	+0.552	<.001	8	view →
LUAD	Male	All	+0.355	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

KIF7–HNSC

Open the HNSC breakdown →