KIF7

Across TCGA patient cohorts, KIF7 mutation is significantly associated with the RNA expression of many other genes, with 3,863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF7-associated genes across cancer lineages are TRAJ12, RNY1P1, and BTG3P1. Each is linked with KIF7 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIF7-to-partner and partner-to-KIF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ12 grouped by KIF7-low versus KIF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF7→partner) and Y-score (partner→KIF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ12 →	+0.351	+1.328	.001	.005	3	4
CESC	RNY1P1 →	+0.118	+3.605	<.001	.002	3	3
ACC	BTG3P1 →	+0.076	+5.228	<.001	.005	3	2
ACC	LINC01950 →	+0.064	+5.228	<.001	.005	3	2
ACC	MIR1299 →	+0.495	+4.887	<.001	.009	3	2
UCEC	CNIH1 →	+0.420	+1.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,863 associations by consensus.

TRAJ12 by KIF7 expression — UCEC

Explore this box plot interactively →