KIF7

Across TCGA cell cohorts, KIF7 mutation is significantly associated with the RNA expression of many other genes, with 1,288 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF7-associated genes across cancer lineages are LYG1, TADA2B, and PDIK1L. Each is linked with KIF7 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF7-to-partner and partner-to-KIF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by KIF7-low versus KIF7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF7→partner) and Y-score (partner→KIF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.986	+2.850	<.001	<.001	3	3
LARGE_INTESTINE	TADA2B →	+0.549	+2.158	.002	.004	3	3
LARGE_INTESTINE	PDIK1L →	+0.716	+3.949	<.001	<.001	3	3
LARGE_INTESTINE	JADE1 →	+0.937	+2.850	<.001	<.001	3	3
LUNG_NSCLC_LUAD	APOBEC4 →	+0.040	+3.343	<.001	.005	3	2
BLOOD_Lymphoma	MROH2B →	+0.069	+4.058	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,288 associations by consensus.

LYG1 by KIF7 expression — LARGE_INTESTINE

Explore this box plot interactively →