KIF6

Across TCGA patient cohorts, KIF6 mutation is significantly associated with the RNA expression of many other genes, with 4,703 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF6-associated genes across cancer lineages are GFI1, ZIC2, and LAG3. Each is linked with KIF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF6-to-partner and partner-to-KIF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFI1 grouped by KIF6-low versus KIF6-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF6→partner) and Y-score (partner→KIF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GFI1 →	+0.885	+3.481	.005	.002	3	3
UCEC	ZIC2 →	+1.790	+2.243	<.001	<.001	3	3
UCEC	LAG3 →	+1.149	+2.536	<.001	<.001	3	3
HNSC	MAGEB6 →	+0.627	+3.039	<.001	.003	3	3
UCEC	CSK →	+0.453	+1.958	<.001	<.001	3	3
UCEC	MICU1 →	+0.289	+1.764	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,703 associations by consensus.

GFI1 by KIF6 expression — BLCA

Explore this box plot interactively →