KIF6

Across TCGA patient cohorts, KIF6 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF6-associated genes across cancer lineages are GAPDH, PCNA, and HER2_pY1248. Each is linked with KIF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF6-to-partner and partner-to-KIF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by KIF6-low versus KIF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF6→partner) and Y-score (partner→KIF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.605	+2.906	<.001	.001	3	3
COAD	PCNA →	+0.294	+2.593	.004	.006	3	3
SKCM	HER2_pY1248 →	-0.168	-3.321	.027	.010	3	3
UCEC	Caspase-7-cleavedD198 →	+0.652	+2.341	.001	.003	3	3
COAD	Notch1 →	+0.176	+3.000	.023	.034	3	2
COAD	PKC-b-II_pS660 →	-0.483	-3.691	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

GAPDH by KIF6 expression — UCEC

Explore this box plot interactively →