KIF6

Across TCGA cell cohorts, KIF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,117 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KIF6-associated GO terms across cancer lineages are Adenylate cyclase-modulating G protein-coupled receptor signaling pathway, Calcium ion transport, and Positive regulation of ATP-dependent activity. Each is linked with KIF6 in more than 8 cancer types. Because this analysis shows association rather than direction, both KIF6-to-partner and partner-to-KIF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-modulating G protein-coupled receptor signaling pathway grouped by KIF6-low versus KIF6-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF6→partner) and Y-score (partner→KIF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.054	-0.567	.001	<.001	3	9
BLOOD_Leukemia	Calcium ion transport →	-0.023	-0.164	.005	.007	3	9
LIVER	Positive regulation of ATP-dependent activity →	+0.094	+0.798	.003	.003	3	8
BREAST	Purine nucleoside triphosphate biosynthetic process →	+0.083	+0.542	<.001	.009	3	8
BREAST	Purine ribonucleoside triphosphate biosynthetic process →	+0.083	+0.542	<.001	.009	3	8
OVARY	Cellular respiration →	+0.089	+0.922	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,117 associations by consensus.

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway by KIF6 expression — SOFT_TISSUE

Explore this box plot interactively →