KIF6

Across TCGA cell cohorts, KIF6 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. CNS shows the largest number of these associations.

The most reproducible KIF6-associated genes across cancer lineages are GHRH, CELA3A, and TMEM235. Each is linked with KIF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF6-to-partner and partner-to-KIF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by KIF6-low versus KIF6-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF6→partner) and Y-score (partner→KIF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GHRH →	+0.094	+3.700	<.001	.003	3	2
CNS	CELA3A →	+0.223	+3.700	<.001	.003	3	2
URINARY_TRACT	TMEM235 →	+0.020	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUSC	CCDC182 →	+0.026	+4.643	<.001	.008	3	1
CNS	CRX →	+1.434	+3.449	.005	.004	3	1
CNS	GNAT1 →	+0.221	+3.710	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

GHRH by KIF6 expression — CNS

Explore this box plot interactively →