KIF5C

Across TCGA pan-cancer cohorts, KIF5C Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated KIF5C data layer compared with 18 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher KIF5C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KIF5C expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

ESCA, CESC, and COAD are the cancer types where KIF5C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.164	0.702	.002	33	view →
CESC	DFS	Median	II,III,IV	0.053	0.786	<.001	30	view →
COAD	OS	Median	III,IV	0.054	0.793	<.001	26	view →
LUAD	OS	Median	All	0.172	0.791	<.001	24	view →
KIRP	OS	Median	All	0.134	0.708	<.001	21	view →
UCEC	OS	Median	II,III,IV	0.904	0.450	.013	20	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
OV	DFS	Median	All	0.132	0.541	.001	6	view →
STAD	DFS	Median	All	1.000	0.337	.046	1	view →
SKCM	DFS	Median	II,III,IV	0.774	0.559	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

KIF5C–ESCA (OS)

Open the ESCA breakdown →