KIF5C-AS1

Across TCGA pan-cancer cohorts, KIF5C-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated KIF5C-AS1 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher KIF5C-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF5C-AS1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and PCPG show a favorable association.

DLBC, CHOL, and LIHC are the cancer types where KIF5C-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	III,IV	0.074	0.984	.003	38	view →
CHOL	OS	Tertile	IV	0.024	0.732	.014	36	view →
LIHC	OS	Median	II,III,IV	0.963	0.660	<.001	27	view →
PCPG	OS	Median	All	1.000	0.631	.008	23	view →
LUAD	OS	Median	All	0.514	0.228	.006	22	view →
LGG	DFS	Quartile	All	0.730	0.868	<.001	21	view →
SKCM	DFS	Tertile	All	0.136	0.349	.003	21	view →
ACC	DFS	Median	II,III,IV	0.378	0.714	.008	19	view →
LAML	DFS	Median	All	0.347	0.566	.001	16	view →
READ	OS	Tertile	IV	1.000	0.606	.022	12	view →
PAAD	DFS	Quartile	All	0.541	0.265	.014	10	view →
BLCA	OS	Median	II,III,IV	0.765	0.653	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

KIF5C-AS1–DLBC (DFS)

Open the DLBC breakdown →