KIF5B

Across TCGA pan-cancer cohorts, KIF5B mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of KIF5B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KIF5B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types KIF5B is over-expressed in tumor.

HNSC, LUAD, and PDAC are the cancer types where KIF5B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIF5B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.231	<.001	11	view →
LUAD	Male	All	+0.217	<.001	8	view →
PDAC	Female	II,III,IV	+0.216	<.001	8	view →
LSCC	Male	All	+0.080	.001	3	view →
OV	All	All	+0.198	.023	2	view →
COAD	Female	II,III,IV	+0.061	.025	2	view →
CCRCC	All	II,III,IV	+0.061	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

KIF5B–HNSC

Open the HNSC breakdown →